Ruslan Efremov will supervise DC4 (Cryo-EM blueprints of kinase dimerization and substrate-site architecture).
The goal of our research is to understand how biological molecular machines work. We use single particle cryogenic electron microscopy (cryo-EM) to solve high-resolution structures of molecular machines and visualise protein conformations associated with their function. In order to advance beyond state of the art we invest efforts in developing new approaches for preparation of cryo-EM samples using microfluidics. We are an interdisciplinary team consisting of structural biologists and engineers working together towards understand how incredibly efficient and versatile molecular machines evolved by within living organisms work.
