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Position 12: LTK (dark kinome) cellular models, phosphoproteomics and interface dependency

Position 12: LTK (dark kinome) cellular models, phosphoproteomics and interface dependency

Position 11: Cellular target engagement and pathway modulation in EGFR/BRAF models

Position 11: Cellular target engagement and pathway modulation in EGFR/BRAF models

Position 10: Deep-learning for polypharmacology, allosterism and resistance-aware interface design

Position 10: Deep-learning for polypharmacology, allosterism and resistance-aware interface design

Position 9: Structure-based & ML pipelines for interface-selective hit discovery

Position 9: Structure-based & ML pipelines for interface-selective hit discovery

Position 8: Design and synthesis of MCR-based dimerization inhibitors.

Position 8: Design and synthesis of MCR-based dimerization inhibitors.

Position 7: PPI-biased small-molecule discovery for kinase regulatory interfaces

Position 7: PPI-biased small-molecule discovery for kinase regulatory interfaces

Position 6: (Bi)cyclic peptide discovery against dimerization and substrate interfaces

Position 6: (Bi)cyclic peptide discovery against dimerization and substrate interfaces

Position 5: SMALP-stabilised kinase reconstitution to bridge structural and cellular states

Position 5: SMALP-stabilised kinase reconstitution to bridge structural and cellular states

Position 1: TR-FRET dimerization reporters for EGFR, BRAF and LTK under ATP-locked conditions

Position 1: TR-FRET dimerization reporters for EGFR, BRAF and LTK under ATP-locked conditions

Position 2: Cleavable-linker bisubstrate FRET assays with covalent ATP anchors

Position 2: Cleavable-linker bisubstrate FRET assays with covalent ATP anchors

Position 3: Single-molecule FRET maps of kinase oligomerization and ligand-biased conformations

Position 3: Single-molecule FRET maps of kinase oligomerization and ligand-biased conformations

Position 4: Cryo-EM blueprints of kinase dimerization and substrate-site architecture

Position 4: Cryo-EM blueprints of kinase dimerization and substrate-site architecture

CONTACT

    ANA-KIN Doctoral Network
    Aristotle University of Thessaloniki
    54124 Thessaloniki
    Greece

    Funded by the European Union under the grant agreement No 101312304. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency (REA). Neither the European Union nor the granting authority can be held responsible for them.

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